Buzz Aldrin may have been the second man on the moon, but he’s also got his eyes set on Hollywood – especially Reese Witherspoon.

The former astronaut, 78, is in talks for a proposed film about the battles he faced after his Apollo flight – and his subsequent love story, he told reporters Thursday at the New York premiere of the animated 3-D feature Fly Me to the Moon. Aldrin did voice work for the film.

As for casting the role of his wife of 20 years, Lois, Aldrin envisions Oscar-winner Witherspoon, 32.

“Lois likes Reese Witherspoon,” he says, “because she played a similar part in Walk the Line.”

In that 2005 film, Witherspoon played June Carter, wife of the erratic country legend Johnny Cash – and the woman who rescued him from the throes of substance abuse.

“My experiences post-flight were ones of not being very productive for quite awhile – depression and alcoholism, things like that,” says Aldrin. “I was trying to recover from that and ran into [Lois] afterwards.”

Asked if Lois straightened him out, Aldrin responded with a laugh. “Nah,” he insists, “I was already straight.”